EBC - ON DEMAND
European Bifurcation Club 2008 – EBC 2008 – Prague, Czech Republic
Conferences
Role of Endothelial Shear Stress in the Natural History of Coronary Atherosclerosis and Remodeling
Author: Yiannis S. Chatzizisis, MD, Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA
CONCLUSION
- Low ESS predicts the development of TCFAs through enhancement of lipid accumulation, inflammation and subsequent upregulation of matrix degrading proteases
- Excessive expansive remodeling self perpetuates a vicious cycle of low ESS and plaque inflammation, thereby facilitating the differentiation of early plaques to TCFAs
- Low ESS may be utilized in man for identification of TCFAs at early stages of development before they rupture. Early identification of TCFAs may facilitate the pre-emptive local intervention to avert future acute coronary events