EBC - ON DEMAND
European Bifurcation Club 2013, EBC 2013 – London, UK
Patient-specific bifurcation stenting simulation
Lesion progression prediction from shear stress and plaque characteristics: PREDICTION
Author: Saeko Takahashi, MD, Shonan Kamakura General Hospital
THE PREDICTION STUDY – PURPOSE
- To characterize the natural history of CAD in consecutive high-risk patients after an acute coronary syndrome (ACS);
- To identify the baseline local ESS, plaque and wall remodeling characteristics that precede the subsequent development of plaque at high risk for developing acute plaque rupture or accelerated luminal obstruction;
- To attribute new clinical events to preceding local hemodynamic (ESS) and anatomic (plaque and arterial remodeling) characteristics.
SUMMARY & CONCLUSION
- Local areas of low ESS develop:
- Significant plaque progression
- Decrease in lumen area
- Independent baseline anatomic predictors of progressive lumen obstruction:
- Large plaque (burden: OR 2.13; area: OR 1.81)
- Low ESS (OR 1.70)
- Results of stented artery and bifurcations will be expected in the future.