EBC - ON DEMAND
European Bifurcation Club 2013, EBC 2013 – London, UK
Patient-specific bifurcation stenting simulation
Patient specific bifurcation stenting modelling: What for? To predict outcome
Author: Yiannis Chatzizisis, MD, PhD, Brigham and Women’s Hospital Harvard Medical School, Boston, USA
FUTURE GOAL #1: BENCH
Refine computer and in-vitro simulations by using:
- Realistic coronary geometries (e.g. CT, 3D IVUS, 3D OCT)
- Realistic wall properties (e.g. elasticity)
- Realistic blood properties (e.g. pulsatile flow)
- Realistic materials (e.g. stent, balloon geometry and material)
FUTURE GOAL #2: ANIMAL STUDIES
Use large animal models (e.g. swine) to assess the effect of mechanical interventions on vascular biology:
- Inflammation
- Stent restenosis
- Stent thrombosis
FUTURE GOAL #3: CLINICAL STUDIES
Need for randomized clinical trials comparing stent geometries and stenting techniques in terms of stent thrombosis and restenosis
Apparently this process
Bench –> Animals –> Clinical Trails
takes time, effort and money