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Role of flow and mechanical factors on neo-intimal hyperplasia after stenting

EBC - ON DEMAND

Role of flow and mechanical factors on neo-intimal hyperplasia after stenting

European Bifurcation Club 2017 – EBC 2017 – Porto, Portugal

SESSION 6: Patient-Specific Simulation Session: From Basics to Practice

Role of flow and mechanical factors on neo-intimal hyperplasia after stenting

Author: GS Kassab, California Medical Innovations

 

INTRODUCTION

  • Fluid wall shear stress (WSS) and intramural circumferential wall stress (CWS) affect endothelial and smooth muscle biology.
  • We hypothesize that the perturbation of WSS and CWS affect neo intimal hyperplasia (IH) after stenting.

CONCLUSION

  • Significant linear relations were found between solid (vessel wall) CWS and fluid WSSG, OSI and IH, while an inverse relations were found between fluid WSS and IH.
  • Even more highly significant linear relations were found between the ratio CWS/WSS and products CWS*WSSG, CWS*OSI and IH.
  • These findings suggest that the effects of both strut flow disturbances and radial wall force on IH are synergistic and should be considered to fully understand the effect of stenting.

 

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