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Stop DAPT2 High Bleeding Risk sub analysis


European Bifurcation Club 2019, EBC 2019 – Barcelona, Spain


STOPDAPT2 HBR Bifurcation. 1 Year outcomes from a Randomized Trial of Clopidogrel Monotherapy VS DAPT Beginning 1 Month After PCI in Patients at High Bleeding Risk

Author: Hirotoshi Watanabe, MD, Kyoto University Hospital, Japan



  • Post-hoc, and underpowered analysis.
  • Precise ARC-HBR could not be applied.
  •  Very few patients participated in this study with 2-stents for bifurcation.
  • Japanese patients are known to have lower ischemic risk and higher bleeding risk compared with US/European population


  • The effects of 1-month DAPT versus 12-month DAPT on the primary and major secondary endpoints were consistent in HBR patients and any bifurcation strategy without any significant interactions.
  • One-month DAPT was associated with significant reduction of major bleeding without any increase of cardiovascular events in HBR patients, and the absolute magnitude of bleeding events with 1-month DAPT was numerically greater in HBR patients than in non-HBR patients, although the analysis was underpowered and needed confirmation in future studies.
  • In this study very few patients with complex PCI for bifurcation participated, but there was no sign 1-month DAPT significantly increased the coronary-related events


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