EBC - ON DEMAND
European Bifurcation Club 2019, EBC 2019 – Barcelona, Spain
LM SESSION
EXCEL 5 Years and SYNTAXES 10 years
Author: Patrick Serruys, MD, PhD, Imperial College London, UK
TAKE HOME MESSAGES (10 years)
- First Randomized Trial to report 10-Year Survival after CABG or PCI with drug-eluting stents in patients with de novo Three-Vessel and Left Main Disease
- Completeness of follow-up at 10-Year = 94% (well-balanced across CABG and PCI)
- No survival difference in between CABG and PCI at 10 years in overall cohort
- Increased survival with CABG vs PCI in Three-Vessel disease
- Comparable survival with CABG vs PCI in Left Main disease
- Non-compliance to the SS II treatment recommendation resulted in a numerically higher risk of all-cause death at 10 years.
TAKE HOME MESSAGES (5 years)
- Four Randomized Trials to report 5-Year Survival after CABG or PCI with drug-eluting stents in patients with de novo Left Main Disease.
- No survival difference in between CABG and PCI at 5 years in the left main disease from a pooled patient level meta analysis.
- In the EXCEL trial, Non-compliance to the SS II treatment recommendation (CABG) resulted in a significantly higher risk of all-cause death when randomised to PCI.
- Compliance to the SS II treatment recommendation (Equipoise) resulted in a non- significant difference in all-cause mortality when randomised to either CABG or PCI.