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EXCEL 5 Years and SYNTAXES 10 years

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EXCEL 5 Years and SYNTAXES 10 years

European Bifurcation Club 2019, EBC 2019 – Barcelona, Spain

LM SESSION

EXCEL 5 Years and SYNTAXES 10 years

Author: Patrick Serruys, MD, PhD, Imperial College London, UK

 

TAKE HOME MESSAGES (10 years)

  1. First Randomized Trial to report 10-Year Survival after CABG or PCI with drug-eluting stents in patients with de novo Three-Vessel and Left Main Disease
  2. Completeness of follow-up at 10-Year = 94% (well-balanced across CABG and PCI)
  3. No survival difference in between CABG and PCI at 10 years in overall cohort
  4. Increased survival with CABG vs PCI in Three-Vessel disease
  5. Comparable survival with CABG vs PCI in Left Main disease
  6. Non-compliance to the SS II treatment recommendation resulted in a numerically higher risk of all-cause death at 10 years.

TAKE HOME MESSAGES (5 years)

  1. Four Randomized Trials to report 5-Year Survival after CABG or PCI with drug-eluting stents in patients with de novo Left Main Disease.
  2. No survival difference in between CABG and PCI at 5 years in the left main disease from a pooled patient level meta analysis.
  3. In the EXCEL trial, Non-compliance to the SS II treatment recommendation (CABG) resulted in a significantly higher risk of all-cause death when randomised to PCI.
  4. Compliance to the SS II treatment recommendation (Equipoise) resulted in a non- significant difference in all-cause mortality when randomised to either CABG or PCI.

 

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