BiOSS Bench Study

EBC 2019 - Barcelona, Spain NEWS 1 BiOSS Lim C bench test Author: Francois Derimay, MD, PhD, Hospices Civils de Lyon, France QUESTIONS & ANSWERS Which scope for the BiOSS Lim C? - Spontaneously, 40% of the expected geometries are possible Which behavior of the diameters during inflation? - Very compliant balloon with homothetic inflation Which use out of scope? - Strict homothetic inflation without over segmentary expansion Which proximal maximum expansion capacity? - Post dilatation capacity ≥ to classical DES What about SB management? - Control of the connector position possibly difficult Non systematic SBI

Learnings From the Bench and a Thrombogenicity Model

European Bifurcation Club 2019, EBC 2019 - Barcelona, Spain NEWS 1 Learnings From the Bench and a Thrombogenicity Model Author: Nicolas Foin, MSc, PhD, National Heart Research Institute Singapore; Philips Healthcare, Belgium LEARNINGS FROM THE BENCH Bench models allow to study questions in controlled and reproducible experimental environments Make use tools such as Micro-CT, Radial & Longitudinal Strength tes;ng, 3D printing, Perfusion test, Histology, SEM Microscopy. LIMITATIONS It can only provide a partial model to investigate a question and cannot mimic the entire tissue /plaque characteristics and in-vivo biological response. Results can not always be transposed directly to in-vivo situations and should be interpreted with caution. Bench models complement, but do not replace clinical/imaging studies SUMMARY Stent underexpansion and stent malapposition distances affect flow disturbances and shear rate in a dose-dependent relation. Severe malapposition (ISA distance > 300 um) create higher shear rate with persitent malapposition + uncovered strut at follow-up. In-vitro experiments with perfused blood suggest that large malapposed stent segment create potential sites for platelet adhesion and clot development. Stent optimisation (expansion and apposition) with appropriate sizing, post-dilatation and imaging can improve local hemodynamic environment and reduce area of high shear disturbance.

DK-Culotte: Bench Evaluation

EBC 2019 - Friday 18th October 2019 DK-Culotte: bench evaluation - Benefits of DK-approach during Culotte stenting Author: Gabor G. Toth, MD, PhD, University Heart Centre Graz, Austria

Risk of stent sizing according to the distal MV in LM bifurcation

European Bifurcation Club 2019, EBC 2019 - Barcelona, Spain BENCH & COMPUTATIONAL BIFURCATION STENT SIMULATIONS Risk of stent sizing according to the distal MV in LM bifurcation Author: Yutaka Hikichi, MD, PhD, Saga University, Japan BACKGROUND AND PURPOSE OF THE EXPERIMENT Size selection: according to the distal MB reference? Hypothesis: Stent size influence the acute outcome Implantation methods CONCLUSION When performing a crossover stent to LMT-LAD, the stent size should be selected according to the vessel diameter on the proximal side of the bifurcation. By selecting a larger stent size, the incomplete stent apposition area can be reduced at the LCx ostium after KBT. By doing so, incomplete stent apposition volume can be reduced at the LM-shaft after KBT , and the stent expansion rate can be greatly increased. The risk of injury on the LAD distal side during stent implantation can be reduced by thorough pre- dilatation and devising the stent placement method.

A new bifurcation bench

European Bifurcation Club 2011, EBC 2011 - Lisbon, Portugal HOT NEWS SESSION A new bifurcation bench Author: Nicolas Foin, MD, Imperial College, Feops, Gent University and the Royal Brompton NHS Trust, London