EXCEL 5 Years and SYNTAXES 10 years

European Bifurcation Club 2019, EBC 2019 - Barcelona, Spain LM SESSION EXCEL 5 Years and SYNTAXES 10 years Author: Patrick Serruys, MD, PhD, Imperial College London, UK TAKE HOME MESSAGES (10 years) First Randomized Trial to report 10-Year Survival after CABG or PCI with drug-eluting stents in patients with de novo Three-Vessel and Left Main Disease Completeness of follow-up at 10-Year = 94% (well-balanced across CABG and PCI) No survival difference in between CABG and PCI at 10 years in overall cohort Increased survival with CABG vs PCI in Three-Vessel disease Comparable survival with CABG vs PCI in Left Main disease Non-compliance to the SS II treatment recommendation resulted in a numerically higher risk of all-cause death at 10 years. TAKE HOME MESSAGES (5 years) Four Randomized Trials to report 5-Year Survival after CABG or PCI with drug-eluting stents in patients with de novo Left Main Disease. No survival difference in between CABG and PCI at 5 years in the left main disease from a pooled patient level meta analysis. In the EXCEL trial, Non-compliance to the SS II treatment recommendation (CABG) resulted in a significantly higher risk of all-cause death when randomised to PCI. Compliance to the SS II treatment recommendation (Equipoise) resulted in a non- significant difference in all-cause mortality when randomised to either CABG or PCI.

Summary and take home messages from Parallel 2

European Bifurcation Club 2014, EBC 2014 - Bordeaux, France PARALLEL SESSIONS SYNOPSIS The Top 3 take home messages from the bifurcation quantitative analysis parallel session Author: Patrick Serruys, MD, PhD, Imperial College London, UK

EXCEL Clinical Trial

European Bifurcation Club 2010, EBC 2010 - Budapest, Hungary LM upcoming studies: place of techniques? EXCEL Clinical Trial Author: Patrick W. Serruys, MD, ErasmusMC, The Netherlands

Three-dimensional angiography pre- and post- Left Main treatment

European Bifurcation Club 2008 - EBC 2008 - Prague, Czech Republic New Bifurcation Assessment techniques Three-dimensional angiography pre- and post- Left Main treatment Author: Patrick W. Serruys, MD, PhD, Thoraxcenter, Erasmus Medical Center R&D Department, Cardialysis, Rotterdam, the Netherlands