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Lesion progression prediction from shear stress and plaque characteristics: PREDICTION

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Lesion progression prediction from shear stress and plaque characteristics: PREDICTION

European Bifurcation Club 2013, EBC 2013 – London, UK

Patient-specific bifurcation stenting simulation

Lesion progression prediction from shear stress and plaque characteristics: PREDICTION

AuthorSaeko Takahashi, MD, Shonan Kamakura General Hospital

 

THE PREDICTION STUDY – PURPOSE

  • To characterize the natural history of CAD in consecutive high-risk patients after an acute coronary syndrome (ACS);
  • To identify the baseline local ESS, plaque and wall remodeling characteristics that precede the subsequent development of plaque at high risk for developing acute plaque rupture or accelerated luminal obstruction;
  • To attribute new clinical events to preceding local hemodynamic (ESS) and anatomic (plaque and arterial remodeling) characteristics.

SUMMARY & CONCLUSION

  • Local areas of low ESS develop:
    • Significant plaque progression
    • Decrease in lumen area
  • Independent baseline anatomic predictors of progressive lumen obstruction:
    • Large plaque (burden: OR 2.13; area: OR 1.81)
    • Low ESS (OR 1.70)
  • Results of stented artery and bifurcations will be expected in the future.

 

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